Neuropsychological Biomarkers
Processing Speed
Slower reaction times on tasks (e.g., Trail Making Test, Symbol Digit Modalities Test) indicate disrupted neural efficiency, commonly seen in mild-to-moderate TBI.
Attention and Concentration
Sustained and divided attention scores on tasks like Continuous Performance Tests (CPT) highlight difficulties maintaining focus — a hallmark symptom after TBI.
Working Memory
Performance on digit span or n-back tasks reflects short-term memory and attention control. Declines suggest injury to frontal or parietal brain networks.
Verbal and Visual Memory
Delayed recall from word lists or visual figure reproduction shows hippocampal or temporal lobe disruption, frequently impacted in traumatic brain injuries.
Executive Functioning
Measures of planning, flexibility, and problem-solving (e.g., Wisconsin Card Sorting Test, Stroop Test) serve as biomarkers of frontal lobe and network integrity.
Emotional and Behavioral Regulation
Validated scales measuring irritability, impulsivity, or mood swings act as biomarkers for orbitofrontal and limbic system dysfunction post-injury.